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Health Information : Osteogenesis Imperfecta

What is osteogenesis imperfecta?

Osteogenesis imperfecta (OI), also known as brittle-bone disease, is a genetic (inherited) disorder characterized by bones that break easily without a specific cause. An estimated 20,000 to 50,000 people in the US have this disease. OI can affect males and females of all races.

What causes osteogenesis imperfecta?

The cause of OI is believed to be due to a genetic defect that causes imperfectly-formed, or an inadequate amount of, bone collagen - a protein found in the connective tissue.

Treatment for osteogenesis imperfecta:


Specific treatment for osteogenesis imperfecta will be determined by your physician based on:

•    your age, overall health, and medical history
•    extent of the disease
•    your tolerance for specific medications, procedures, or therapies
•    expectations for the course of the disease
•    your opinion or preference